Seppic targets GLP-1 side effects with new botanical strategies

The global market for GLP-1 companion products is projected to more than double between 2026 and 2033, a growth trajectory that signals a major shift in how the supplement industry approaches weight loss support. This expansion is not driven by a desire for stronger appetite suppression, but rather by a growing consumer demand to mitigate the physical trade-offs of these potent therapies. The most pressing concerns reported by patients and observed by clinicians include non-scarring hair loss and facial sagging following substantial weight reduction. These aesthetic and physiological issues are becoming the primary drivers for new product development in the wellness sector.

Seppic, a major player in cosmetic and nutritional ingredients, is moving aggressively into this space with a strategy that blends botanical science with longevity research. Their approach treats the body as a system where cellular health directly impacts visible signs of aging and tissue integrity. By focusing on specific botanical extracts that target hair follicles and skin elasticity, the company is offering a concrete solution to the side effects that have historically limited the adoption of GLP-1 medications among appearance-conscious consumers. This is not just about adding another vitamin to the mix, but about addressing the structural changes that occur during rapid metabolic shifts.

The Hair and Skin Gap

Reports of hair thinning linked to GLP-1 treatment have become a widespread concern in both clinical settings and social media communities. This phenomenon creates a significant barrier for many potential users who fear that their hair will not recover after the weight loss journey concludes. Seppic has identified this as a critical opportunity for intervention, specifically through their ingredient CERAMOSIDE. This wheat-derived phytoceramide is designed to support hair density and scalp health during periods of rapid physiological change. The company claims that this ingredient provides clinically demonstrated benefits for hair loss at a low dose, offering a targeted response to a widespread complaint.

The effectiveness of CERAMOSIDE is supported by data showing visible results for hair within two months of consistent use. This timeline is significant because it aligns with the period during which many patients experience the most noticeable hair shedding. By providing a countermeasure that shows measurable progress in this specific window, the ingredient offers a practical tool for formulators and consumers alike. The focus on hair is not an isolated effort, as the same ingredient also addresses skin elasticity, creating a dual-purpose solution that tackles two of the most visible side effects of rapid weight loss simultaneously.

Cellular Foundations

Beyond the visible symptoms of hair loss and skin changes, Seppic is anchoring its strategy in the broader context of cellular health and longevity. The company is leveraging its expertise in NAD+ research, a molecule that plays a crucial role in cellular energy and repair. NAD+ precursor supplement sales are projected to grow by 61% between 2025 and 2027, indicating a strong consumer interest in anti-aging and metabolic health. Seppic’s Sepibliss, a patented natural coriander seed extract, is positioned to go beyond simple NAD+ replenishment by targeting inflammation and oxidative stress. These two factors are key drivers of NAD+ depletion, and addressing them offers a more comprehensive approach to cellular vitality.

The integration of Sepibliss into GLP-1 companion concepts represents a sophisticated understanding of how metabolic interventions impact the body at a molecular level. By combining this extract with NAD+ in new liposomal pouches developed with formulation partner Virun, Seppic is creating a product that supports internal cellular function while also addressing external aesthetic concerns. This dual approach allows brands to market a solution that speaks to both the scientific mechanisms of aging and the practical needs of consumers undergoing significant lifestyle changes. The company’s focus on clinically demonstrated improvements in signs of skin aging within just two weeks further strengthens the case for this combination, providing quick, visible wins that build consumer confidence.

Cognitive and Aesthetic Balance

Seppic’s longevity portfolio also includes SEPIBRIGHT, an eco-designed nootropic ingredient derived from upcycled strawberry leaves. This extract is standardized in polyphenols and ellagitannins and has been clinically demonstrated to benefit long-term memory, learning capabilities, and stress reduction. The inclusion of cognitive support in a GLP-1 companion strategy reflects a holistic view of health during periods of metabolic stress. Rapid weight loss can be physically and mentally taxing, and providing ingredients that support cognitive sharpness adds another layer of value to the overall wellness package. This ingredient was unveiled at Vitafoods Europe 2026, signaling its importance in the company’s current product offerings.

The combination of hair support, skin elasticity, cellular health, and cognitive function creates a comprehensive narrative for GLP-1 users. It moves the conversation away from viewing weight loss as a singular event and toward understanding it as a complex physiological process that requires multi-faceted support. By addressing the specific needs associated with each stage of the metabolic shift, Seppic is providing formulators with a toolkit that covers a wide range of consumer concerns. This strategy is particularly relevant as the market for these companion products continues to expand rapidly, with projections indicating a more than doubling of the global market size by 2033.

Market Implications

The rapid growth of the GLP-1 companion market presents a significant opportunity for ingredient suppliers who can offer scientifically backed solutions to the side effects of these drugs. Seppic’s strategy of combining botanical extracts with longevity research positions it as a leader in this emerging sector. The company’s focus on specific, clinically demonstrated outcomes provides a clear value proposition for brands looking to differentiate their products in a crowded marketplace. By addressing the most common complaints about GLP-1 therapy, such as hair loss and skin changes, Seppic is meeting a real and urgent consumer need.

This approach also highlights the increasing importance of cross-functional health solutions that bridge the gap between nutrition, cosmetics, and pharmaceutical support. The success of these companion products will likely depend on their ability to deliver visible and tangible results within a reasonable timeframe. Seppic’s ingredients, with their documented timelines for visible improvement, are well-suited to meet this demand. As the GLP-1 market continues to mature, the role of complementary wellness products will become increasingly central to the overall treatment experience, making strategic positioning in this space essential for industry leaders.